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A Phase 1, First-in-Human, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 562 in Subjects With Relapsed / Refractory Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, or Follicular Lymphoma

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Trial Profile

A Phase 1, First-in-Human, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 562 in Subjects With Relapsed / Refractory Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, or Follicular Lymphoma

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 26 Mar 2024

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At a glance

  • Drugs AMG-562 (Primary)
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man
  • Sponsors Amgen

    • Most Recent Events

    • 28 Jan 2021 Planned End Date changed from 20 Jun 2021 to 26 Mar 2022.
    • 28 Jan 2021 Planned primary completion date changed from 20 Jun 2021 to 26 Mar 2022.
    • 28 Oct 2020 Status changed from active, no longer recruiting to discontinued, according to an Amgen media release. AS, development of AMG-562 for non-Hodgkin's lymphoma has been stopped due to portfolio prioritization.

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