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A Phase I, adaptive, open-label, single ascending dose to single-blind, placebo-controlled, multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of mRNA-0184 in participants with chronic heart failure

Trial Profile

A Phase I, adaptive, open-label, single ascending dose to single-blind, placebo-controlled, multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of mRNA-0184 in participants with chronic heart failure

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 20 Mar 2025

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At a glance

  • Drugs MRNA-0184 (Primary)
  • Indications Chronic heart failure
  • Focus Adverse reactions; First in man
  • Sponsors AstraZeneca; Moderna Therapeutics

Most Recent Events

  • 17 Mar 2025 Status changed from active, no longer recruiting to completed.
  • 20 Nov 2023 Planned End Date changed from 7 May 2024 to 6 Mar 2025.
  • 20 Nov 2023 Planned primary completion date changed from 7 May 2024 to 6 Mar 2025.

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