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Phase 1/2 Trial of Intratumoral Administration of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon Beta (VSV-IFNβ-NIS) Monotherapy and in Combination With Avelumab in Patients With Refractory Solid Tumors

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Phase 1/2 Trial of Intratumoral Administration of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon Beta (VSV-IFNβ-NIS) Monotherapy and in Combination With Avelumab in Patients With Refractory Solid Tumors

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 07 Jul 2023

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At a glance

  • Drugs Avelumab (Primary) ; VSV-IFNbeta-NIS (Primary) ; VSV-IFNbeta-NIS (Primary)
  • Indications Colorectal cancer; Pancreatic cancer; Phaeochromocytoma; Sarcoma; Solid tumours; Squamous cell cancer; T-cell lymphoma
  • Focus Adverse reactions; First in man
  • Sponsors Vyriad

    • Most Recent Events

    • 06 Jun 2023 Results (n=17) reporting preliminary pharmacokinetic and safety data in patients given one intravenous dose of VV1 presented at the 59th Annual Meeting of the American Society of Clinical Oncology
    • 25 Apr 2022 Status changed from active, no longer recruiting to completed.
    • 06 Jul 2021 Status changed from recruiting to active, no longer recruiting.

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