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A Phase 1, First-in-human, Open-label, Dose Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral TP-1287 to Patients With Advanced Solid Tumors

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Trial Profile

A Phase 1, First-in-human, Open-label, Dose Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral TP-1287 to Patients With Advanced Solid Tumors

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 15 Mar 2024

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At a glance

  • Drugs TP 1287 (Primary)
  • Indications Advanced breast cancer; Bladder cancer; Ewing's sarcoma; Liposarcoma; Malignant melanoma; Medulloblastoma; Neuroblastoma; Prostate cancer; Renal cell carcinoma; Sarcoma; Small cell lung cancer; Solid tumours; Synovial sarcoma
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Sumitomo Pharma America; Sumitomo Pharma Oncology

    • Most Recent Events

    • 08 Mar 2024 Status changed from recruiting to discontinued.
    • 06 Jun 2023 Phase 1 dose-escalation in solid tumors has completed and TP-1287 is being investigated in a dose expansion cohort in patients with Ewing sarcoma
    • 06 Jun 2023 Trial design of the expansion part, presented at the 59th Annual Meeting of the American Society of Clinical Oncology
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