Trial Profile

A Phase 2 Evaluation of VGX-3100, a Synthetic DNA Immunotherapy Targeting Human Papillomavirus 16 and 18 E6 and E7 Proteins, for Anal High-Grade Squamous Intraepithelial Lesions (HSIL) in HIV-Positive Individuals

Status: Completed

Phase of Trial: Phase II

Latest Information Update: 29 Jul 2025

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At a glance

Drugs Bizalimogene ralaplasmid (Primary)
Indications Anal intraepithelial neoplasia; Human papillomavirus infections; Squamous cell cancer
Focus Therapeutic Use

16 Jul 2025 Status changed from active, no longer recruiting to completed.
11 Apr 2025 Planned End Date changed from 19 Jan 2027 to 17 Jun 2026.
11 Apr 2025 Planned primary completion date changed from 19 Jan 2026 to 17 Jun 2025.

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