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Safety, Immunogenicty and Anti-Reservoir Activity of an Electroporation-Administered HIV DNA Vaccine Encoding GAG, POL and ENV Proteins With IL-12 Plasmid in HIV-Infected Adults on Antriretroviral Therapy

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Trial Profile

Safety, Immunogenicty and Anti-Reservoir Activity of an Electroporation-Administered HIV DNA Vaccine Encoding GAG, POL and ENV Proteins With IL-12 Plasmid in HIV-Infected Adults on Antriretroviral Therapy

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 02 Jun 2023

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At a glance

  • Drugs HIV DNA vaccine (Primary) ; INO 9012 (Primary) ; INO-6145 (Primary)
  • Indications HIV-1 infections
  • Focus Adverse reactions; Pharmacodynamics; Proof of concept
  • Acronyms PENNVAX

    • Most Recent Events

    • 22 Feb 2023 Results assessing the immunologic signatures, at the cellular and transcriptional level, that correlate with augmented HIV-specific T cell responses post-vaccination in 30 participants with HIV who received an HIV DNA vaccine/IL-12 in the PENNVAX clinical trial, presented at the 30th Conference on Retroviruses and Opportunistic Infections 2023.
    • 22 Feb 2023 Results assessing the virologic outcomes of Gag+Pol+IL-12 DNA (G/P), Gag+Pol+Env+IL-12 DNA (G/P/E) in participants with HIV on suppressive antiretroviral therapy, presented at the 30th Conference on Retroviruses and Opportunistic Infections 2023.
    • 16 Feb 2022 Results presented at the 29th Conference on Retroviruses and Opportunistic Infections

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