Trial Profile

REACTION (Radiation Enhanced Assessment of Combination Therapies in Immuno-ONcology) - Nivolumab or Nivolumab in Combination With Other Immuno-oncology (IO) Agents After Targeted Systemic Radiation in Patients With Advanced Esophagogastric Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 14 Jan 2026

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At a glance

Drugs Nivolumab (Primary) ; Relatlimab (Primary)
Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer; Squamous cell cancer
Focus Therapeutic Use
Acronyms REACTION

22 Dec 2025 Planned End Date changed from 1 Dec 2025 to 1 Dec 2026.
22 Dec 2025 Planned primary completion date changed from 1 Dec 2025 to 1 Apr 2026.
11 Dec 2024 Planned End Date changed from 1 Apr 2025 to 1 Dec 2025.

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