Trial Profile

A Phase II Study of Adjuvant PALbociclib as an Alternative to CHemotherapy in Elderly patientS With High-risk ER+/HER2- Early Breast Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 04 Jun 2026

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At a glance

Drugs Palbociclib (Primary) ; Cyclophosphamide; Docetaxel; Doxorubicin; Epirubicin; Paclitaxel
Indications Early breast cancer; HER2 negative breast cancer; Male breast cancer
Focus Therapeutic Use
Acronyms APPALACHES

Most Recent Events

12 May 2026 Planned End Date changed from 30 Sep 2032 to 30 Sep 2026.
12 May 2026 Planned primary completion date changed from 30 Jun 2026 to 30 Sep 2026.
23 Jan 2024 Planned primary completion date changed from 30 Sep 2027 to 30 Jun 2026.

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