Trial Profile

A Phase 1 Study of Adding Venetoclax to a Reduced Intensity Conditioning Regimen and to Maintenance in Combination With a Hypomethylating Agent After Allogeneic Hematopoietic Cell Transplantation for Patients With High Risk AML, MDS, and MDS/MPN Overlap Syndromes

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 03 Oct 2025

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At a glance

Drugs Venetoclax (Primary) ; Azacitidine; Blood mononuclear cell therapy; Busulfan; Cedazuridine/decitabine; Fludarabine; Methotrexate; Tacrolimus
Indications Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes; Myeloproliferative disorders
Focus Adverse reactions

29 Aug 2025 Status changed from recruiting to active, no longer recruiting.
27 Feb 2025 Planned number of patients changed from 100 to 102.
27 Feb 2025 Planned primary completion date changed from 1 Feb 2025 to 1 Dec 2025.

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