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Two-arm randomized phase II trial to assess the feasibility and efficacy of a treatment with Durvalumab a PDL1-Inhibitor plus Tremelimumab a CTLA-4- Inhibitor in combination with radiotherapy and a treatment with Durvalumab in combination with radiotherapy as first-line therapy for patients with non-resectable locally advanced HPV negative HNSCC- A COMPARISON WITH A HISTORICAL CONTROL GROUP-- DuTRe-raD

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Trial Profile

Two-arm randomized phase II trial to assess the feasibility and efficacy of a treatment with Durvalumab a PDL1-Inhibitor plus Tremelimumab a CTLA-4- Inhibitor in combination with radiotherapy and a treatment with Durvalumab in combination with radiotherapy as first-line therapy for patients with non-resectable locally advanced HPV negative HNSCC- A COMPARISON WITH A HISTORICAL CONTROL GROUP-- DuTRe-raD

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 09 Nov 2023

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary)
  • Indications Head and neck cancer; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms DURTRE-RAD

Most Recent Events

  • 09 Nov 2023 This trial has been completed in Germany, according to European Clinical Trials Database record.
  • 06 Jun 2023 Status changed from recruiting to discontinued.
  • 06 Jun 2023 Interim results of feasibility analysis presented at the 59th Annual Meeting of the American Society of Clinical Oncology

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