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A phase II, multicenter, randomized, two-arm study of capmatinib (INC280, an oral MET inhibitor) and spartalizumab (PDR001, a PD-1 inhibitor) combination therapy versus docetaxel in pretreated adult patients with EGFR wild-type, ALK rearrangement negative locally advanced/metastatic non-small cell lung cancer.

Trial Profile

A phase II, multicenter, randomized, two-arm study of capmatinib (INC280, an oral MET inhibitor) and spartalizumab (PDR001, a PD-1 inhibitor) combination therapy versus docetaxel in pretreated adult patients with EGFR wild-type, ALK rearrangement negative locally advanced/metastatic non-small cell lung cancer.

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 05 Nov 2019

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At a glance

  • Drugs Capmatinib (Primary) ; Spartalizumab (Primary) ; Docetaxel
  • Indications Carcinoma; Non-small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Novartis Pharma A.G.; Novartis Pharmaceuticals
  • Most Recent Events

    • 30 Jun 2019 Planned End Date changed from 22 Dec 2021 to 18 Jan 2022.
    • 30 Jun 2019 Planned primary completion date changed from 22 Dec 2021 to 18 Jan 2022.
    • 09 Jan 2019 Status changed from not yet recruiting to recruiting.
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