A Phase II Trial to Investigate Genetic Markers of Response to Pembrolizumab (MK-3475, SCH 900475) Combined With Chemotherapy as a First-line Treatment for Non-Small Cell Lung Cancer (KEYNOTE-782)
Latest Information Update: 26 Aug 2024
At a glance
- Drugs Pembrolizumab (Primary) ; Carboplatin; Cisplatin; Pemetrexed
- Indications Non-small cell lung cancer
- Focus Pharmacodynamics; Therapeutic Use
- Acronyms KEYNOTE-782
- Sponsors Merck Sharp & Dohme Corp.
- 04 Jun 2024 Primary endpoint (Objective Response Rate) has not been met.
- 04 Jun 2024 Results examining relationships between the T-cell-inflamed gene expression profile (TcellinfGEP) and other tumor microenvironment consensus signatures and efficacy of pembrolizumab + chemotherapy in an exploratory analysis of KEYNOTE-782 were presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
- 10 Apr 2024 Results presented at the 115th Annual Meeting of the American Association for Cancer Research