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A Randomized, Open-Label, Phase 2 Study of Nivolumab in Combination With Ipilimumab or Nivolumab Monotherapy in Participants With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H)

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Trial Profile

A Randomized, Open-Label, Phase 2 Study of Nivolumab in Combination With Ipilimumab or Nivolumab Monotherapy in Participants With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 30 Aug 2024

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At a glance

  • Drugs Ipilimumab (Primary) ; Nivolumab (Primary)
  • Indications Advanced breast cancer; CNS cancer; Colorectal cancer; Small cell lung cancer; Solid tumours; Uterine cancer
  • Focus Therapeutic Use
  • Acronyms CheckMate 848
  • Sponsors Bristol-Myers Squibb

Most Recent Events

  • 22 Aug 2023 Status changed from active, no longer recruiting to completed.
  • 13 Apr 2022 Results of an analysis assessed the tissue- and plasma-derived tumor mutational burden and genomic alterations of interest presented at the 113th Annual Meeting of the American Association for Cancer Research
  • 13 Apr 2022 Results of the interim and final analyses for the tTMB-H and bTMB-H cohorts respectively presented at the 113th Annual Meeting of the American Association for Cancer Research

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