Trial Profile

A Randomized Phase 2 Study of Losartan and Nivolumab in Combination With FOLFIRINOX and SBRT in Localized Pancreatic Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 13 Oct 2025

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At a glance

Drugs Fluorouracil (Primary) ; Folinic acid (Primary) ; Irinotecan (Primary) ; Losartan (Primary) ; Nivolumab (Primary) ; Oxaliplatin (Primary)
Indications Adenocarcinoma; Pancreatic cancer; Pancreatic ductal carcinoma
Focus Therapeutic Use

Most Recent Events

01 Oct 2025 Planned End Date changed from 1 Jun 2027 to 1 Apr 2027.
01 Oct 2025 Actual primary completion date changed from 12 Jul 2022 to 16 Feb 2022.
21 Jan 2023 Results comparig the R0 resection rate on each of Arms 2 and 3 independently versus Arm 1 at a one-sided 0.10 level in borderline resectable and locally advanced pancreatic ductal adenocarcinoma presented at the 2023 Gastrointestinal Cancers Symposium

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