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Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3β) Inhibitor, as a Single Agent and Combined With Chemotherapy, in Patients With Refractory Hematologic Malignancies or Solid Tumors

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Trial Profile

Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3β) Inhibitor, as a Single Agent and Combined With Chemotherapy, in Patients With Refractory Hematologic Malignancies or Solid Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Apr 2026

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At a glance

  • Drugs Elraglusib (Primary) ; Carboplatin; Doxorubicin; Gemcitabine; Irinotecan; Lomustine; Paclitaxel
  • Indications Adenocarcinoma; Advanced breast cancer; Anaplastic astrocytoma; Appendiceal cancer; Astrocytoma; CNS cancer; Colorectal cancer; Glioblastoma; Glioma; Haematological malignancies; Liver cancer; Male breast cancer; Malignant melanoma; Merkel cell carcinoma; Non-small cell lung cancer; Oesophageal cancer; Oligodendroglioma; Pancreatic cancer; Pancreatic ductal carcinoma; Parotid neoplasms; Peritoneal cancer; Precursor T-cell lymphoblastic leukaemia-lymphoma; Renal cell carcinoma; Salivary gland cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms Actuate 1801
  • Sponsors Actuate Therapeutics

Most Recent Events

  • 14 Apr 2026 According to an Actuate Therapeutics media release, new data form this trial were published in Nature Medicine.
  • 14 Apr 2026 Results presented in the Actuate Therapeutics Media Release.
  • 03 Apr 2026 Planned End Date changed from 1 Jan 2026 to 1 Jun 2026.

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