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A phase Ib study of Nivolumab plus Trastuzumab with S-1/Capecitabine plus Oxaliplatin for HER2 positive advanced gastric cancer

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A phase Ib study of Nivolumab plus Trastuzumab with S-1/Capecitabine plus Oxaliplatin for HER2 positive advanced gastric cancer

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 15 Dec 2023

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At a glance

  • Drugs Capecitabine (Primary) ; Gimeracil/oteracil/tegafur (Primary) ; Nivolumab (Primary) ; Oxaliplatin (Primary) ; Trastuzumab (Primary)
  • Indications Adenocarcinoma; Gastric cancer
  • Focus Adverse reactions
  • Acronyms Ni-HIGH study

    • Most Recent Events

    • 24 Oct 2023 Results (n=21) analyzing Clinical relevance of circulating tumor DNA in HER2 -positive advanced gastric cancer, presented at the 48th European Society for Medical Oncology Congress
    • 24 Oct 2023 Results (n=23) assessing APC mutation MYC, and GATA6 amplifications association with worse survival in HER2-positive advanced gastric cancer patients treated with S-1/capecitabine plus oxaliplatin combined with trastuzumab and nivolumab presented at the 48th European Society for Medical Oncology Congress
    • 24 Oct 2023 Results assessing the clinical significance of ERBB2 amplification and TMB-H for T-mab plus N-mab with S-1/Capecitabine plus oxaliplatin new combination therapy, presented at the 48th European Society for Medical Oncology Congress.

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