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Response to the HEPLISAV-B Hepatitis B Vaccine in Treatment Naive Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's -Tyrosine Kinase Inhibitor (BTK-I)

Trial Profile

Response to the HEPLISAV-B Hepatitis B Vaccine in Treatment Naive Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's -Tyrosine Kinase Inhibitor (BTK-I)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 09 Feb 2022

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At a glance

  • Drugs Adjuvanted Hepatitis-B vaccine (Recombinant)-Dynavax (Primary)
  • Indications Hepatitis B
  • Focus Pharmacodynamics
  • Most Recent Events

    • 17 Dec 2020 Status changed from recruiting to completed.
    • 01 Dec 2020 Results (n=121) of two studies (NCT03685708 (Hep-CpG) and NCT03702231 (RZV)) assessing effect of BTKi's on de novo immune response against recombinant hepatitis B vaccine and recall response against recombinant zoster vaccine in chronic lymphocytic leukemia patients who were treatment naive or on Bruton's -Tyrosine Kinase Inhibitor, published in the Blood.
    • 20 Aug 2020 Planned number of patients changed from 123 to 108.
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