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A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of an Anti-OX40 Monoclonal Antibody (KHK4083) in Subjects with Moderate to Severe Atopic Dermatitis (AD)

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Trial Profile

A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of an Anti-OX40 Monoclonal Antibody (KHK4083) in Subjects with Moderate to Severe Atopic Dermatitis (AD)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 May 2024

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At a glance

  • Drugs Rocatinlimab (Primary)
  • Indications Atopic dermatitis
  • Focus Therapeutic Use
  • Sponsors Kyowa Kirin; Kyowa Kirin Pharmaceutical Development
  • Most Recent Events

    • 12 Mar 2024 Results assessing whether rocatinlimab improved pNRS and EASI by Week 2; improvements continued and were maintained off-treatment until the end of study, presented at the American Academy of Dermatology annual Meeting 2024
    • 14 Feb 2024 According to the Kyowa Kirin Media Release, data from this study will be presented at the upcoming American Academy of Dermatology (AAD) 2024 Annual Meeting in San Diego from March 8-12, 2024.
    • 11 Oct 2023 According to the Kyowa Kirin Media Release, the company announced that post-hoc analysis data from the Phase 2b study of rocatinlimab (AMG 451/KHK4083),in patients with moderate-to-severe atopic dermatitis (AD), will be presented at the upcoming European Academy of Dermatology and Venereology (EADV) Congress 2023 in Berlin, Germany.

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