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A Phase 1/2, Randomized, Double-blind, Placebo-controlled, Single-ascending and Multiple-dose, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of Subcutaneously Administered ALN-AAT02 in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Trial Profile

A Phase 1/2, Randomized, Double-blind, Placebo-controlled, Single-ascending and Multiple-dose, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of Subcutaneously Administered ALN-AAT02 in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 09 Aug 2019

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At a glance

  • Drugs ALN-AAT02 (Primary)
  • Indications Alpha 1-antitrypsin deficiency; Liver disorders
  • Focus Adverse reactions
  • Sponsors Alnylam Pharmaceuticals
  • Most Recent Events

    • 06 Aug 2019 Status changed from recruiting to active, no longer recruiting.
    • 24 Jun 2019 New source identified and integrated (European Clinical Trials Database; EudraCT2018-001362-41)
    • 07 Feb 2019 According to an Alnylam Pharmaceuticals media release, initial results are expected in 2019.
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