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Phase Ib Trial With Dose Expansion of the Bruton"s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination With Rituximab and Lenalidomide in Patients With Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL)

Trial Profile

Phase Ib Trial With Dose Expansion of the Bruton"s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination With Rituximab and Lenalidomide in Patients With Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 02 Feb 2026

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At a glance

  • Drugs Ibrutinib (Primary) ; Lenalidomide; Rituximab
  • Indications Diffuse large B cell lymphoma; Nervous system neoplasms
  • Focus Adverse reactions

Most Recent Events

  • 29 Jan 2026 Status changed from active, no longer recruiting to completed.
  • 02 Dec 2025 Planned End Date changed from 1 Nov 2025 to 1 Nov 2026.
  • 02 Dec 2025 Planned primary completion date changed from 1 Nov 2025 to 1 Nov 2026.

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