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A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib in Patients With Metastatic Castration-Resistant Prostate Cancer

Trial Profile

A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib in Patients With Metastatic Castration-Resistant Prostate Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase II/III

Latest Information Update: 10 Mar 2025

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At a glance

  • Drugs Abemaciclib (Primary) ; Abiraterone acetate; Prednisolone; Prednisone
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Therapeutic Use
  • Acronyms CYCLONE 2
  • Sponsors Eli Lilly and Company

Most Recent Events

  • 04 Jun 2024 Primary endpoint (Radiographic Progression Free Survival (rPFS)) has not been met.
  • 04 Jun 2024 Primary results (n=393) of CYCLONE 2 study presented at the 60th Annual Meeting of the American Society of Clinical Oncology
  • 23 May 2024 According to an Eli Lilly and Company media release, data from this trial will be presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting taking place May 31 - June 4 in Chicago.

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