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A Phase III, Randomised,Double-Blind,Placebo-Controlled,Study of Durvalumab as Consolidation Therapy in Patients With Locally Advanced,Unresectable NSCLC, Who Have Not Progressed Following Definitive, Platinum-Based Chemoradiation Therapy

Trial Profile

A Phase III, Randomised,Double-Blind,Placebo-Controlled,Study of Durvalumab as Consolidation Therapy in Patients With Locally Advanced,Unresectable NSCLC, Who Have Not Progressed Following Definitive, Platinum-Based Chemoradiation Therapy

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 02 Mar 2026

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At a glance

  • Drugs Durvalumab (Primary)
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms PACIFIC-5
  • Sponsors AstraZeneca

Most Recent Events

  • 10 Feb 2026 According to AstraZeneca media release, based on this study, Imfinzi is approved in China in Nov 2025 Unresectable Stage III NSCLC with no known sensitising EGFRm or ALK rearrangements whose disease has not progressed.
  • 25 Jul 2025 Planned End Date changed from 16 Mar 2027 to 28 Feb 2027.
  • 24 May 2024 This trial has been completed in Poland, according to European Clinical Trials Database record.

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