Trial Profile

A Phase 3, Randomized, Comparator-controlled Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in Participants With High-risk Non-muscle Invasive Bladder Cancer (HR NMIBC) That is Either Persistent or Recurrent Following BCG Induction or That is Naïve to BCG Treatment (KEYNOTE-676)

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 12 Sep 2025

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At a glance

Drugs Bladder cancer vaccine (Primary) ; Bladder cancer vaccine (Primary) ; Pembrolizumab (Primary)
Indications Bladder cancer; Carcinoma
Focus Registrational; Therapeutic Use
Acronyms KEYNOTE-676
Sponsors Merck Sharp & Dohme Corp.

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