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A Phase III, randomized clinical trial in second line patients comparing the combination of sitravatinib plus a checkpoint inhibitor to docetaxel in patients whose tumors have progressed on prior checkpoint inhibitor therapy

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Trial Profile

A Phase III, randomized clinical trial in second line patients comparing the combination of sitravatinib plus a checkpoint inhibitor to docetaxel in patients whose tumors have progressed on prior checkpoint inhibitor therapy

Status: Planning
Phase of Trial: Phase III

Latest Information Update: 23 Nov 2018

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At a glance

  • Drugs Sitravatinib (Primary) ; Docetaxel
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Sponsors Mirati Therapeutics

    • Most Recent Events

    • 06 Nov 2018 According to a Mirati Therapeutics media release, the company plans to begin this trial in the first half of 2019.
    • 26 Oct 2018 New trial record
    • 22 Oct 2018 According to a Mirati Therapeutics media release, this trial is based on guidance received from the FDA in an end of Phase 2 meeting. The trial will include an interim analysis of overall response rate (ORR) as a surrogate endpoint to serve as the basis for potential Subpart H accelerated approval.

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