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A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib in First-line Therapy of Participants With Advanced Hepatocellular Carcinoma (LEAP-002)

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Trial Profile

A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib in First-line Therapy of Participants With Advanced Hepatocellular Carcinoma (LEAP-002)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 27 May 2025

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At a glance

  • Drugs Lenvatinib (Primary) ; Pembrolizumab (Primary)
  • Indications Carcinoma; Liver cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms LEAP-002
  • Sponsors Merck Sharp & Dohme

Most Recent Events

  • 20 May 2025 According to an Eisai Inc media release, findings from this study will be presented in a poster presentation at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting (#ASCO25), which is taking place in Chicago, Illinois from May 30 to June 3.
  • 10 Oct 2024 Status changed from active, no longer recruiting to completed.
  • 23 Sep 2024 This trial has been completed in Ireland, according to European Clinical Trials Database record.

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