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A Multicenter, Open-Label, Dose Escalation Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of the DNA-PK Inhibitor M3814 in Combination With Avelumab With and Without Palliative Radiotherapy in Participants With Selected Advanced Solid Tumors

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A Multicenter, Open-Label, Dose Escalation Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of the DNA-PK Inhibitor M3814 in Combination With Avelumab With and Without Palliative Radiotherapy in Participants With Selected Advanced Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 17 Apr 2025

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At a glance

  • Drugs Avelumab (Primary) ; Peposertib (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors EMD Serono

    • Most Recent Events

    • 29 Nov 2022 Status changed from active, no longer recruiting to completed.
    • 06 Apr 2022 Planned End Date changed from 17 May 2022 to 13 Sep 2022.
    • 06 Apr 2022 Status changed from recruiting to active, no longer recruiting.

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