Either you have JavaScript disabled or your browser does not support Javascript . To work properly, this page requires JavaScript to be enabled.
How to enable JavaScript in your browser?

A Phase 1, Open-Label, Fixed-sequence, 5-part, Drug-drug Interaction Study of Tucatinib to Evaluate the Effects of CYP3A4 and CYP2C8 Inhibition and Induction on the Pharmacokinetics of Tucatinib and to Evaluate the Effects of Tucatinib on the Pharmacokinetics of Substrates of CYP3A4, CYP2C8, CYP2C9, and P-glycoprotein in Healthy Male and Female Subjects

Trial Profile

A Phase 1, Open-Label, Fixed-sequence, 5-part, Drug-drug Interaction Study of Tucatinib to Evaluate the Effects of CYP3A4 and CYP2C8 Inhibition and Induction on the Pharmacokinetics of Tucatinib and to Evaluate the Effects of Tucatinib on the Pharmacokinetics of Substrates of CYP3A4, CYP2C8, CYP2C9, and P-glycoprotein in Healthy Male and Female Subjects

Completed
Phase of Trial: Phase I

Latest Information Update: 22 Jan 2019

At a glance

  • Drugs Tucatinib (Primary) ; Digoxin; Gemfibrozil; Itraconazole; Midazolam; Repaglinide; Rifampicin; Tolbutamide
  • Indications Breast cancer; Colorectal cancer
  • Focus Pharmacokinetics
  • Sponsors Seattle Genetics
  • Most Recent Events

    • 14 Jan 2019 Status changed from recruiting to completed.
    • 21 Dec 2018 Planned End Date changed from 1 Nov 2018 to 1 Dec 2018.
    • 21 Dec 2018 Planned primary completion date changed from 1 Nov 2018 to 1 Dec 2018.
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at AsktheExpert.AdisInsight@springer.com so we can help.

Back to top