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A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Phase 1b Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL747 in Subjects With Amyotrophic Lateral Sclerosis

Trial Profile

A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Phase 1b Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL747 in Subjects With Amyotrophic Lateral Sclerosis

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 14 May 2020

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At a glance

  • Drugs DNL-747 (Primary)
  • Indications Amyotrophic lateral sclerosis
  • Focus Adverse reactions
  • Sponsors Denali Therapeutics Inc
  • Most Recent Events

    • 12 May 2020 Planned End Date changed from 26 May 2021 to 1 Jun 2021.
    • 02 Apr 2020 According to a Denali Therapeutics media release, Denali continues to collect data from the ongoing Phase 1b open-label extension study in ALS. Analysis of data from these trials is underway and Denali is on track to decide on next steps with DNL747 by mid-2020 together with its partner Sanofi
    • 31 Mar 2020 Planned End Date changed from 1 Dec 2020 to 26 May 2021.
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