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A Randomized Phase II Study of Pembrolizumab With or Without Defactinib, a Focal Adhesion Kinase Inhibitor Following Chemotherapy as a Neoadjuvant and Adjuvant Treatment for Resectable Pancreatic Ductal Adenocarcinoma (PDAC)

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Trial Profile

A Randomized Phase II Study of Pembrolizumab With or Without Defactinib, a Focal Adhesion Kinase Inhibitor Following Chemotherapy as a Neoadjuvant and Adjuvant Treatment for Resectable Pancreatic Ductal Adenocarcinoma (PDAC)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 09 Feb 2026

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At a glance

  • Drugs Defactinib (Primary) ; Pembrolizumab (Primary)
  • Indications Adenocarcinoma; Pancreatic cancer; Pancreatic ductal carcinoma
  • Focus Therapeutic Use

Most Recent Events

  • 04 Feb 2026 Status changed from active, no longer recruiting to completed.
  • 05 Aug 2025 Planned End Date changed from 10 Jul 2025 to 15 Jan 2026.
  • 02 Apr 2025 Planned End Date changed from 1 Dec 2024 to 10 Jul 2025.

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