Trial Profile

A Single-Arm, Open-Label, Phase 1 Study of the Safety, Efficacy, and Cellular Kinetics/Pharmacodynamics of ALLO-715 to Evaluate an Anti-BCMA Allogeneic CAR T Cell Therapy With or Without Nirogacestat in Subjects With Relapsed/Refractory Multiple Myeloma

Status: Completed

Phase of Trial: Phase I/II

Latest Information Update: 19 May 2026

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At a glance

Drugs Allo 715 (Primary) ; ALLO 647; Cyclophosphamide; Fludarabine; Nirogacestat
Indications Multiple myeloma
Focus Adverse reactions; First in man; Proof of concept; Registrational
Acronyms UNIVERSAL
Sponsors Allogene Therapeutics

13 May 2026 Status changed from active, no longer recruiting to completed.
09 Aug 2023 Planned End Date changed from 1 Dec 2027 to 1 Sep 2027.
09 Aug 2023 Planned primary completion date changed from 1 Dec 2022 to 1 Sep 2027.

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