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A Single-Arm, Open-Label, Phase 1 Study Evaluating the Safety, Efficacy, and Cellular Kinetics/Pharmacodynamics of ALLO-501, an Anti-CD19 Allogeneic CAR T Cell Therapy, And ALLO-647, An Anti-CD52 Monoclonal Antibody, in Patients With Relapsed/Refractory Large B-Cell Lymphoma or Follicular Lymphoma

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Trial Profile

A Single-Arm, Open-Label, Phase 1 Study Evaluating the Safety, Efficacy, and Cellular Kinetics/Pharmacodynamics of ALLO-501, an Anti-CD19 Allogeneic CAR T Cell Therapy, And ALLO-647, An Anti-CD52 Monoclonal Antibody, in Patients With Relapsed/Refractory Large B-Cell Lymphoma or Follicular Lymphoma

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 20 Feb 2025

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At a glance

  • Drugs Allo 501 (Primary) ; ALLO 647; Cyclophosphamide; Fludarabine
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; First in man; Registrational; Therapeutic Use
  • Acronyms ALPHA
  • Sponsors Allogene Therapeutics

Most Recent Events

  • 13 Feb 2025 Results presented in the Allogene Therapeutics Media Release.
  • 13 Feb 2025 According to an Allogene Therapeutics media release, durable response data from Phase 1 ALPHA and ALPHA2 clinical studies of cemacabtagene ansegedleucel in relapsed/refractory large B-cell lymphoma published as a Rapid Communication in the Journal of Clinical Oncology.
  • 12 Dec 2023 Results (n=87) an analysis assessing safety data of ALLO-647 in patients with r/r LBCL and follicular lymphoma (FL) from two clinical studies: ALPHA and ALPHA2 presented at the 65th American Society of Hematology Annual Meeting and Exposition

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