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A Phase 1, Open-Label, Multicenter, Dose Escalation Study of mRNA-2752, a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L, IL-23, and IL-36γ, for Intratumoral Injection Alone and in Combination With Immune Checkpoint Blockade

Trial Profile

A Phase 1, Open-Label, Multicenter, Dose Escalation Study of mRNA-2752, a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L, IL-23, and IL-36γ, for Intratumoral Injection Alone and in Combination With Immune Checkpoint Blockade

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 30 Oct 2019

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At a glance

  • Drugs Durvalumab (Primary) ; MRNA 2752 (Primary) ; Tremelimumab (Primary)
  • Indications Lymphoma; Solid tumours
  • Focus Adverse reactions
  • Sponsors Moderna Therapeutics
  • Most Recent Events

    • 16 Oct 2019 Planned number of patients changed from 130 to 126.
    • 16 Oct 2019 Planned End Date changed from 1 Nov 2021 to 1 Jun 2021.
    • 16 Oct 2019 Planned primary completion date changed from 1 Aug 2020 to 1 Jun 2020.
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