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A Phase II Study of Anti-PD1 Monoclonal Antibody (Nivolumab, BMS-936558) Administered in Combination With Anti-LAG3 Monoclonal Antibody (Relatlimab, BMS-986016) in Patients With Metastatic Melanoma Naïve to Prior Immunotherapy in the Metastatic Setting

Trial Profile

A Phase II Study of Anti-PD1 Monoclonal Antibody (Nivolumab, BMS-936558) Administered in Combination With Anti-LAG3 Monoclonal Antibody (Relatlimab, BMS-986016) in Patients With Metastatic Melanoma Naïve to Prior Immunotherapy in the Metastatic Setting

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 01 Oct 2024

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At a glance

  • Drugs Nivolumab (Primary) ; Relatlimab (Primary)
  • Indications Malignant melanoma
  • Focus Pharmacodynamics; Therapeutic Use

Most Recent Events

  • 23 Sep 2024 Status changed from active, no longer recruiting to completed.
  • 04 Jun 2024 Results assessing objective response rate (ORR) at week (wk) 4 and 16, progression-free survival (PFS) for pts receiving lead-in with nivo or rela vs. combination, and correlations with immune-related pathological response (irPR) at wk 4 tumor biopsy, presented at the 60th Annual Meeting of the American Society of Clinical Oncology
  • 06 Sep 2023 Planned End Date changed from 31 Jul 2023 to 31 Jul 2027.

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