A Phase IB/II, 2-stage, Open-label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab (MEDI4736) + Paclitaxel and Durvalumab (MEDI4736) in Combination With Novel Oncology Therapies With or Without Paclitaxel for First-line Metastatic Triple Negative Breast Cancer
Latest Information Update: 07 Nov 2025
At a glance
- Drugs Capivasertib (Primary) ; Danvatirsen (Primary) ; Datopotamab deruxtecan (Primary) ; Durvalumab (Primary) ; Oleclumab (Primary) ; Paclitaxel (Primary) ; Selumetinib (Primary) ; Trastuzumab-deruxtecan (Primary)
- Indications Advanced breast cancer; HER2 negative breast cancer; Triple negative breast cancer
- Focus Adverse reactions; Therapeutic Use
- Acronyms BEGONIA
- Sponsors AstraZeneca; AstraZeneca AB
Most Recent Events
- 19 Oct 2025 According to Daiichi Sankyo Company Media Release, data from this study were presented at the 2025 European Society for Medical Oncology Congress.
- 13 Oct 2025 According to Daiichi Sankyo Company Media Release, data from this study will be presented at the 2025 European Society for Medical Oncology Congress.
- 27 Jan 2025 Planned End Date changed from 29 Nov 2024 to 26 Feb 2027.