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A Phase IB/II, 2-stage, Open-label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab (MEDI4736) + Paclitaxel and Durvalumab (MEDI4736) in Combination With Novel Oncology Therapies With or Without Paclitaxel for First-line Metastatic Triple Negative Breast Cancer

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A Phase IB/II, 2-stage, Open-label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab (MEDI4736) + Paclitaxel and Durvalumab (MEDI4736) in Combination With Novel Oncology Therapies With or Without Paclitaxel for First-line Metastatic Triple Negative Breast Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 30 Jan 2025

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At a glance

  • Drugs Capivasertib (Primary) ; Danvatirsen (Primary) ; Datopotamab deruxtecan (Primary) ; Durvalumab (Primary) ; Oleclumab (Primary) ; Paclitaxel (Primary) ; Selumetinib (Primary) ; Trastuzumab-deruxtecan (Primary)
  • Indications Advanced breast cancer; HER2 negative breast cancer; Triple negative breast cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms BEGONIA
  • Sponsors AstraZeneca; AstraZeneca AB

    • Most Recent Events

    • 27 Jan 2025 Planned End Date changed from 29 Nov 2024 to 26 Feb 2027.
    • 12 Jul 2024 Planned End Date changed from 14 Nov 2024 to 29 Nov 2024.
    • 12 Jul 2024 Planned primary completion date changed from 14 Nov 2024 to 29 Nov 2024.

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