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A Single-Arm, Multi-Center, Open-Label, Phase 2 Study to Evaluate Efficacy and Safety of Tislelizumab (BGB-A317), an Anti-PD-1 Monoclonal Antibody, as Monotherapy in Patients With Previously-Treated Locally Advanced Unresectable or Metastatic Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Solid Tumors

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A Single-Arm, Multi-Center, Open-Label, Phase 2 Study to Evaluate Efficacy and Safety of Tislelizumab (BGB-A317), an Anti-PD-1 Monoclonal Antibody, as Monotherapy in Patients With Previously-Treated Locally Advanced Unresectable or Metastatic Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Solid Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 08 Dec 2024

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At a glance

  • Drugs Tislelizumab (Primary)
  • Indications Colorectal cancer; Gastric cancer; Oesophageal cancer; Solid tumours
  • Focus Registrational; Therapeutic Use
  • Acronyms RATIONALE 209
  • Sponsors BeiGene

    • Most Recent Events

    • 24 Oct 2023 Results of updated analysis of longer follow up presented at the 48th European Society for Medical Oncology Congress
    • 13 Dec 2022 Planned number of patients changed from 80 to 200.
    • 13 Dec 2022 Planned End Date changed from 1 Dec 2022 to 1 Sep 2027.

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