A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy
Latest Information Update: 12 Jan 2026
At a glance
- Drugs Atezolizumab (Primary) ; Cabozantinib (Primary) ; Sorafenib
- Indications Liver cancer
- Focus Registrational; Therapeutic Use
- Acronyms Cosmic; COSMIC-312
- Sponsors Exelixis
Most Recent Events
- 11 Dec 2025 Planned End Date changed from 1 Dec 2024 to 31 Jul 2026.
- 11 Dec 2025 Actual primary completion date changed from 8 Mar 2021 to 30 Nov 2021.
- 31 Aug 2024 This trial has been completed in Czechia according to European Clinical Trials Database record.