A Multicenter, Open Label, Phase II Basket Trial Exploring the Efficacy and Safety of the Combination of Rucaparib (PARP Inhibitor) and Atezolizumab (Anti-PD-L1 Antibody) in Patients With DNA Repair-deficient or Platinum-sensitive Solid Tumors
Latest Information Update: 13 Jun 2025
At a glance
- Drugs Atezolizumab (Primary) ; Rucaparib (Primary)
- Indications Adenocarcinoma; Bladder cancer; Carcinoma; Gastric cancer; Non-small cell lung cancer; Oesophageal cancer; Prostate cancer; Renal cell carcinoma; Urogenital cancer
- Focus Therapeutic Use
- Acronyms ARIANES
Most Recent Events
- 30 Apr 2025 Results assessing multi-omics analysis on sequential patient samples, including single-cell RNA + T-cell receptor sequencing (scRNA+TCR-Seq) and bulk RNA-Seq on sequential tumor biopsies, concomitant plasma proteomics, and whole exome sequencing, presented at the 116th Annual Meeting of the American Association for Cancer Research.
- 25 Mar 2024 Planned primary completion date changed from 1 Apr 2024 to 1 Dec 2024.
- 19 Jan 2023 Status changed from recruiting to suspended.