A Multicenter Study With an Open-label Phase Ib Part Followed by a Randomized, Placebo-controlled, Double-blind, Phase II Part to Evaluate Efficacy, Safety, Tolerability, and Pharmacokinetics of the DNA-PK Inhibitor Peposertib (M3814) in Combination With Capecitabine and RT in Participants With Locally Advanced Rectal Cancer
Latest Information Update: 23 Mar 2023
At a glance
- Drugs Capecitabine (Primary) ; Peposertib (Primary)
- Indications Adenocarcinoma; Rectal cancer
- Focus Adverse reactions
- Sponsors EMD Serono Research & Development Institute; Merck KGaA
Most Recent Events
- 17 Mar 2022 Status changed from active, no longer recruiting to completed.
- 25 Aug 2021 Planned End Date changed from 6 Jul 2023 to 17 Feb 2022.
- 15 Aug 2021 This trial has been discontinued in Italy.