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A Phase 1/2, Open Label, Dose Escalation, and Cohort Expansion Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/HER2-) Locally Advanced or Metastatic Breast Cancer, Who Have Received Prior Hormonal Therapy and Chemotherapy in the Locally Advanced/Metastatic Setting

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Trial Profile

A Phase 1/2, Open Label, Dose Escalation, and Cohort Expansion Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/HER2-) Locally Advanced or Metastatic Breast Cancer, Who Have Received Prior Hormonal Therapy and Chemotherapy in the Locally Advanced/Metastatic Setting

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 27 May 2025

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At a glance

  • Drugs Palbociclib (Primary) ; Vepdegestrant (Primary)
  • Indications Advanced breast cancer; HER2 negative breast cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms mBC; VERITAC
  • Sponsors Arvinas

Most Recent Events

  • 20 May 2025 Planned End Date changed from 13 Mar 2025 to 30 Aug 2025.
  • 16 May 2024 According to an Arvinas media release, results were presented at the 2024 European Society for Medical Oncology (ESMO) Breast Cancer Annual Congress.
  • 16 May 2024 Results presented in an Arvinas media release.

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