Trial Profile

A Phase II Randomized, Multi-Center, Double-Blind, Global Study to Determine the Efficacy and Safety of Durvalumab Plus Olaparib Combination Therapy Compared With Durvalumab Monotherapy as Maintenance Therapy in Patients Whose Disease Has Not Progressed Following Standard of Care Platinum-Based Chemotherapy With Durvalumab in First Line Stage IV Non Small Cell Lung Cancer (ORION)

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 16 Dec 2024

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At a glance

Drugs Durvalumab (Primary) ; Olaparib (Primary) ; Carboplatin; Cisplatin; Gemcitabine; Paclitaxel; Pemetrexed
Indications Non-small cell lung cancer; Squamous cell cancer
Focus Therapeutic Use
Acronyms ORION
Sponsors AstraZeneca

11 Dec 2024 Planned End Date changed from 27 Sep 2024 to 26 Sep 2025.
15 Sep 2024 The trial has been completed in Hungary according to European Clinical Trials Database record.
12 Jan 2024 Planned End Date changed from 29 Sep 2024 to 27 Sep 2024.

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