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A Randomised, Multicentre, Investigator-Blind, Parallel-Group Trial to Evaluate the Efficacy and Safety of MC2-01 Cream Compared to Vehicle and Active Comparator in Subjects with Mild-to-Moderate Psoriasis Vulgaris

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Trial Profile

A Randomised, Multicentre, Investigator-Blind, Parallel-Group Trial to Evaluate the Efficacy and Safety of MC2-01 Cream Compared to Vehicle and Active Comparator in Subjects with Mild-to-Moderate Psoriasis Vulgaris

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 13 Jan 2026

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At a glance

Most Recent Events

  • 18 Dec 2025 According to Knight Therapeutics media release, the company announced that Health Canada has approved WYNZORA indicated for the topical treatment of psoriasis vulgaris in adults and adolescents aged 12-17 years for up to 8 weeks. The Health Canada approval is based on the results of two randomized, investigator-blind, vehicle-controlled 8-week trials (MC2-01-C2 and MC2-01-C7) in adults.
  • 01 Nov 2023 Results published in the Journal of the European Academy of Dermatology and Venereology
  • 25 Jul 2023 Results of pooled post hoc analysis assessing the efficacy of CAL/BDP polyaphron dispersion (PAD)-cream in subgroups of patients with moderate-to-severe psoriasis from two completed phase 3 studies (NCT03308799 and NCT03802344) conducted in the USA and Europe, published in the Dermatology and Therapy.

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