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An Open Label Phase I PET Imaging Study to Investigate the Bio-distribution and Tumor Uptake of [89Zr]Zr-BI 754111 in Patients With Advanced Non-small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma Treated With BI 754111 in Combination With BI 754091

Trial Profile

An Open Label Phase I PET Imaging Study to Investigate the Bio-distribution and Tumor Uptake of [89Zr]Zr-BI 754111 in Patients With Advanced Non-small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma Treated With BI 754111 in Combination With BI 754091

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 19 Apr 2024

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At a glance

  • Drugs Ezabenlimab (Primary) ; Miptenalimab (Primary)
  • Indications Head and neck cancer; Non-small cell lung cancer; Squamous cell cancer
  • Focus Pharmacokinetics
  • Sponsors Boehringer Ingelheim

Most Recent Events

  • 30 Mar 2024 Results assessing safety, maximum tolerated dose (MTD), pharmacokinetics and antitumour activity of ezabenlimab in Study 1381.1 (NCT02952248), Study 1381.4 (NCT03433898) and Study 1381.3 (NCT03780725) published in the Cancer Immunology Immunotherapy.
  • 13 Sep 2021 Status changed from completed to discontinued.
  • 17 Dec 2020 Status changed from active, no longer recruiting to completed.

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