Trial Profile

A 12-month, Open-label, Multicenter, Randomized, Safety, Efficacy, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Two Regimens of Anti-CD40 Monoclonal Antibody, CFZ533 vs. Standard of Care Control, in Adult de Novo Liver Transplant Recipients With a 12-month Additional Follow-up and a Long-term Extension (CONTRAIL I)

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 30 Jan 2025

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At a glance

Drugs Iscalimab (Primary) ; Iscalimab (Primary) ; Corticosteroids; Mycophenolate mofetil; Mycophenolate mofetil; Prednisone; Tacrolimus; Tacrolimus
Indications Liver transplant rejection
Focus Therapeutic Use
Acronyms CONTRAIL I
Sponsors Novartis Pharma A.G.; Novartis Pharmaceuticals

06 Jun 2024 Status changed from completed to discontinued.
04 Feb 2024 This trial has been discontinued in Italy, according to European Clinical Trials Database record.
12 Jul 2023 Status changed from active, no longer recruiting to completed.

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