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A Phase 1b/2, Open-Label Study Evaluating the Safety and Efficacy of KRT-232 in Patients With p53 Wild-Type (p53WT) Merkel Cell Carcinoma (MCC) Who Have Failed Anti-PD-1 or Anti-PD-L1 Immunotherapy, or in Combination With Avelumab in MCC Patients Who Are Anti-PD-1 or Anti-PD-L1 Treatment Naïve

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Trial Profile

A Phase 1b/2, Open-Label Study Evaluating the Safety and Efficacy of KRT-232 in Patients With p53 Wild-Type (p53WT) Merkel Cell Carcinoma (MCC) Who Have Failed Anti-PD-1 or Anti-PD-L1 Immunotherapy, or in Combination With Avelumab in MCC Patients Who Are Anti-PD-1 or Anti-PD-L1 Treatment Naïve

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 26 Oct 2023

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At a glance

  • Drugs Avelumab (Primary) ; Navtemadlin (Primary)
  • Indications Merkel cell carcinoma
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Acronyms NOTOS
  • Sponsors Kartos Therapeutics

    • Most Recent Events

    • 26 Oct 2023 This trial has been discontinued in Netherland and Germany (End Date: 28 Sep 2023), according to the European Clinical Trials Database record.
    • 07 Oct 2023 This trial has been discontinued in Spain.
    • 06 Jun 2023 Study design presented at the 59th Annual Meeting of the American Society of Clinical Oncology.

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