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Multicenter, Open-Label, Single Arm, Phase II Exploratory Study to Evaluate the Effect of a One-Year Consolidation Treatment With Ponatinib 15 mg on Treatment Free-Remission Rate in Patients With Philadelphia-Positive Chronic Myeloid Leukemia, Who Had Previously Achieved a Deep Molecular Response With Imatinib

Trial Profile

Multicenter, Open-Label, Single Arm, Phase II Exploratory Study to Evaluate the Effect of a One-Year Consolidation Treatment With Ponatinib 15 mg on Treatment Free-Remission Rate in Patients With Philadelphia-Positive Chronic Myeloid Leukemia, Who Had Previously Achieved a Deep Molecular Response With Imatinib

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 24 Jan 2024

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At a glance

  • Drugs Ponatinib (Primary)
  • Indications Chronic myeloid leukaemia
  • Focus Therapeutic Use
  • Acronyms PONAZERO
  • Most Recent Events

    • 12 Dec 2023 Results (n=23)presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 15 Jun 2023 Interim results of PONAZERO (NCT04043676) & RESTOP (NCT04160546) assessing use of ponatinib 15mg daily for 12 months, presented at the 28th Congress of the European Haematology Association.
    • 22 Feb 2023 Results (n=9) evaluating the persistence of TKI-mediated protective activity against HIV in CD4 from individuals who received one-year treatment with ponatinib against chronic myeloid leukemia, presented at the 30th Conference on Retroviruses and Opportunistic Infections 2023

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