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A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab With or Without Eflornithine (DFMO) in Children With Relapsed, Refractory or Progressive Neuroblastoma

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A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab With or Without Eflornithine (DFMO) in Children With Relapsed, Refractory or Progressive Neuroblastoma

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 14 Apr 2025

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At a glance

  • Drugs Dinutuximab (Primary) ; Eflornithine (Primary) ; Eflornithine (Primary) ; Irinotecan (Primary) ; Sargramostim (Primary) ; Sargramostim (Primary) ; Temozolomide (Primary) ; Temozolomide (Primary)
  • Indications Neuroblastoma
  • Focus Therapeutic Use

    • Most Recent Events

    • 09 Apr 2025 Planned End Date changed from 31 Mar 2025 to 7 Apr 2026.
    • 27 Feb 2024 Planned End Date changed from 30 Jun 2024 to 31 Mar 2025.
    • 27 Feb 2024 Planned primary completion date changed from 30 Jun 2024 to 31 Mar 2025.

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