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A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Ipatasertib in Combination With Atezolizumab and Paclitaxel or Nab-Paclitaxel in Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer

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Trial Profile

A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Ipatasertib in Combination With Atezolizumab and Paclitaxel or Nab-Paclitaxel in Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 05 Nov 2024

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At a glance

  • Drugs Atezolizumab (Primary) ; Cyclophosphamide (Primary) ; Doxorubicin (Primary) ; Ipatasertib (Primary) ; Paclitaxel (Primary)
  • Indications Advanced breast cancer; Male breast cancer; Triple negative breast cancer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Roche

Most Recent Events

  • 30 Oct 2024 Safety primary endpoint added newly. Timeframe for efficacy endpoints has been changed.
  • 07 Dec 2023 Results from NCT03800836, NCT03337724 and NCT04177108 ; evaluating a triplet regimen combining immune checkpoint blockade, AKT pathway inhibition, and (nab)paclitaxel as first-line therapy for locally advanced/metastatic triple-negative breast cancer published in the Clinical Cancer Research
  • 22 Apr 2022 Status changed from active, no longer recruiting to completed.

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