Trial Profile

A Randomized, Double-blind, Multi-center, Phase III Clinical Study Assessing the Efficacy and Safety of Sintilimab ± IBI305 Combined With Pemetrexed and Cisplatin in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer Who Have Failed Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI) Treatment (ORIENT-31)

Status: Completed

Phase of Trial: Phase III

Latest Information Update: 29 Nov 2023

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At a glance

Drugs Bevacizumab (Primary) ; Cisplatin (Primary) ; Pemetrexed (Primary) ; Sintilimab (Primary)
Indications Non-small cell lung cancer
Focus Registrational; Therapeutic Use
Acronyms ORIENT-31
Sponsors Innovent Biologics

23 Nov 2023 Status changed from recruiting to completed.
08 May 2023 Second interim analysis and survival analysis results have been published in the Lancet Respiratory Medicine.
08 May 2023 Results presented in an Innovent Biologics Media Release.

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