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A Phase III Open-label, Multicenter, Randomized Trial of Adjuvant Palbociclib in Combination With Endocrine Therapy Versus Endocrine Therapy Alone for Patients With Hormone Receptor Positive / HER2-negative Resected Isolated Locoregional Recurrence of Breast Cancer

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A Phase III Open-label, Multicenter, Randomized Trial of Adjuvant Palbociclib in Combination With Endocrine Therapy Versus Endocrine Therapy Alone for Patients With Hormone Receptor Positive / HER2-negative Resected Isolated Locoregional Recurrence of Breast Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 10 Mar 2025

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At a glance

  • Drugs Palbociclib (Primary) ; Aromatase inhibitors; Fulvestrant; LHRH receptor agonists; Selective estrogen receptor modulators; Tamoxifen
  • Indications Advanced breast cancer; HER2 negative breast cancer; Male breast cancer
  • Focus Therapeutic Use
  • Acronyms POLAR

    • Most Recent Events

    • 07 Mar 2025 Planned End Date changed from 1 Nov 2027 to 1 Jan 2029.
    • 07 Mar 2025 Planned primary completion date changed from 1 Jan 2025 to 27 Jan 2026.
    • 07 Mar 2025 Status changed from recruiting to active, no longer recruiting.

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